Granulopenia and Sulfa Drugs
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چکیده
منابع مشابه
Tetrahydrobiopterin biosynthesis as an off-target of sulfa drugs.
The introduction of sulfa drugs for the chemotherapy of bacterial infections in 1935 revolutionized medicine. Although their mechanism of action is understood, the molecular bases for most of their side effects remain obscure. Here, we report that sulfamethoxazole and other sulfa drugs interfere with tetrahydrobiopterin biosynthesis through inhibition of sepiapterin reductase. Crystal structure...
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